Mutagenic effect of primovlar contraceptive tablets on E. coli

ABSTRACT

This study was carried out to determine if there is any mutagenic effect for Primovlar, the oral contraceptive tablets, on E. coil isolated from normal vagina. It was found that primovar stimulated E. coli growth in low doses and inhibited it in high doses in both complete minimal media. Higher percentage of mutants were obtained following the drug treatment than spontaneously with higher percentage of uracil-requiring mutants. This study proved that the induced uracil-requiring mutants were functional indicating the possibility of carcinogenicity for the drug