Visfatin and its relationship with the severity of coronary artery disease in Pakistani population

ABSTRACT

To determine plasma visfatin in patients with and without coronary artery disease and to correlate it with the coronary vessels blockage by using anagiography. Comparative Cross Sectional Study. This study was conducted at the Department of Biochemistry, Ziauddin University and Jinnah Medical and Dental College, Karachi from June 2009 to November 2010. The study includes 80 subjects [mean age 48.8 +/- 6.15; 40-55 years age range] who underwent coronary angiography for suspected coronary artery disease. Plasma visfatin levels were determined by using ELISA. Out of these 80 study subjects, 30 [37.5%] had single vessel CAD, 12 [15%] had two vessels CAD, 24 [30%] had three vessels CAD and 14 [17.5%] had non significant disease. Serum Visfatin levels were higher in three vessel disease [5.82 +/- 0.58] when compared with non significant [4.55 +/- 1.10] single vessel disease [4.86 +/- 0.93] and two vessels disease [5.53 +/- 0.79] respectively but these values were statistically nonsignificant in all four study groups. Serum Visfatin levels were high in all three study groups when compared with non significant disease group and positive correlation of serum visfatin with the extent of the coronary artery disease was observed