Role of synbiotics in the treatment of childhood constipation: a double-blind randomized placebo controlled trial
Iranian Journal of Pediatrics. 2010; 20 (4): 387-392
Dans Anglais
| IMEMR
| ID: emr-125685
ABSTRACT
Constipation is a common problem in children. There is some clinical evidence for the role of probiotics and prebiotics in the treatment of constipated children. This is the first study on the therapeutic effect of synbiotics [combination of probiotics and prebiotic] in treatment of childhood constipation. In a double-blind randomized placebo controlled study 102 children aged 4-12 years with functional constipation were assessed according to Rome III criteria for 4 weeks. They were divided into 3 groups group A, received 1.5 ml/kg/day oral liquid paraffin plus placebo, group B, 1 sachet symbiotic per day plus placebo and group C, 1.5 ml/kg/day oral liquid paraffin plus 1 sachet symbiotic per day. Frequency of bowel movements [BMs], stool consistency, number of fecal incontinence episodes, abdominal pain, painful defecation per week, success of treatment and side effects were determined in each group before and after treatment. The frequency of BMs per week increased in all groups [P<0.001], but it differed between groups and was higher in group C [P=0.03]. Stool consistency increased and number of fecal incontinence episodes, abdominal pain and painful defecation per week decreased in all groups similarly and there was statistically no difference between them. No side effects were reported in group B; the main side effect in group A and C was seepage of oil [P<0.001]. Treatment success was similar in all groups without any significant difference between them [P=0.6]. This study showed that synbiotics have positive effects on symptoms of childhood constipation without any side effects
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Paraffine
/
Placebo
/
Huiles
/
Enfant
/
Méthode en double aveugle
/
Probiotiques
/
Prébiotiques
/
Synbiotiques
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Iran. J. Pediatr.
Année:
2010
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS