Egyptian Journal of Histology [The]. 2012; 35 (2): 353-365
Dans Anglais
| IMEMR
| ID: emr-126570
ABSTRACT
Cisplatin [CP] is one of the most frequently used antineoplastic agents for various types of tumors. Royal jelly [RJ] is a health tonic widely consumed nowadays with various benefits. To evaluate the effect of CP on rat testes and investigate the possible protective effect of RJ on CP- induced testicular lesions. Twenty-four adult albino rats were used. They were divided into four groups of six animals each. Group I served as the control group. Group II comprised rats that received a single intraperitoneal injection of CP[7mg/kg]. Group III comprised rats that received CP [as in group II] plus RJ, which was administered daily by gavage at a dose of 100mg/kg for 10 days. Group IV comprised rats that received RJ alone at the same previous dose. At the end of the experiment, both testes were weighed and prepared for histological, immunological, and electron microscopic studies. Blood samples were taken to measure plasma testosterone level, and morphometric studies were conducted. The results showed that CP had serious deleterious effects on testicular structure and function. RJ reduced the changes occurring with CP administration and caused improvement in the structure and function of rat testes. RJ has a protective effect on CP- induced testicular lesions and can be used in patients who undergo treatment with CP
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Rats
/
Testicule
/
Mâle
/
Immunohistochimie
/
Résultat thérapeutique
/
Agents protecteurs
/
Acides gras
/
Histologie
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Egypt. J. Histol.
Année:
2012
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS