Synthesis of novel 1,4-disubstituted piperazines as potential antihypertensive agents
Egyptian Journal of Pharmaceutical Sciences. 1989; 30 (1-4): 419-27
Dans Anglais
| IMEMR
| ID: emr-12798
ABSTRACT
Two series of 1-arylpiperazines linked to nicotinic acid moiety were prepared as potential antihypertensive agents. The first series [compounds II] was prepared via the Mannich reaction of N-nicotinoyl with 4-amino-benzoic acid to give N-nicotinoyl-4-aminobenzoic acid. The latter was treated with thionyl chloride to give the corresponding acid chloride which was reacted with 1-arylpiperazines to give IV. Preliminary screening of the synthesized compounds was performed for their antihypertensive activity
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Indice:
Méditerranée orientale
Sujet Principal:
Antihypertenseurs
langue:
Anglais
Texte intégral:
Egypt. J. Pharm. Sci.
Année:
1989
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