Some amino derivatives of 4-substituted -a-phenylpropiophenones and their antimicrobial activity

ABSTRACT

Aminomethylation of p-CH3OC6H4 COCH2C6H5 [I] using formaldehyde solution and different amines gave the corresponding new 4-methoxy- alpha-phenyl-beta-aminopropio-phenone derivatives III a-c. The Mannich reaction was run for p-HOC6H4 COCH2C6H3 [II] using different amines to yield the new [IV a-d]. Glyoxalic acid may replace formaldehyde in the Mannich reaction of II with morpholine to produce the new morpholinium salt V of the corresponding amino acid. Hydrolysis of the salt gave the unsaturated acid VI which was esterified to the ester VII. Compound IIIc was found to be active against gram positive bacteria [Bacillus subtilus], IVd and VI found to be active against fungi [A. niger], whileas VI and VII found to be active against gram negative bacteria [E. coli]