vitro antibacterial activity of lomefloxacin and comparison with ciprofloxacin and norfloxacin

ABSTRACT

Lomefloxacin, a defluoridated quinolone has broad antibacterial activity. The objective of this study was to determine the in vitro activity of Lomefloxacin against bacterial strains isolated from respiratory and urinary tract infection. Comparison of Lomefloxacin with Ciprofloxacin and Norfloxacin was also determined. 250 bacterial strains were investigated. 44 strains were from respiratory tract infection [RTI] and 206 strains were from urinary tract infection [UTI]. Minimum inhibitory concentration [MIC] was determined by incorporating the antibiotic in Isosensitivity agar. Comparison of Lomefloxacin with Ciprofloxacin and Norfloxacin antibiotic discs was also determined. Results indicted sensitivity of clinical isolates to Lomefloxacin. MIC ranged from 2 to 10 microg /ml. 90% of K. pneumoniae were inhibited with 2 microg/ml. 70% of all isolates from respiratory tract were sensitive to 5 microg/ml. From UTI more than 75% of all isolates were inhibited by 5 microg/ml except E.coli and Pseudomonas spp. Disc sensitivity pattern indicate Ciprofloxacin as the most effective antibiotic against all isolates from RTI and UTI. Sensitivity of Lomefloxacin and Norfloxacin was similar except S.aureus which was more sensitive to Norfloxacin. MIC method is a reliable and efficient method for the determination of sensitivity pattern of antibiotics as it does not have the problem of expired discs or storage conditions