Terpenoids from Juniperus procera with hepatoprotective activity
Pakistan Journal of Pharmaceutical Sciences. 2012; 25 (2): 315-322
Dans Anglais
| IMEMR
| ID: emr-128883
ABSTRACT
The petroleum ether fraction of Juniperus procera showed significant activity as hepatoprotective when investigated against carbon tetrachloride induced liver injury. The hepatoprotective activity was evaluated through the quantification of biochemical parameters and confirmed using histopathology analysis. Phytochemical investigation of the petroleum ether fraction utilizing different chromatographic techniques resulted in the isolation of six known diterpenoids namely 4-epi-abietol [1], ferruginol [2], hinokiol [3], sugiol [4], Z-communic acid [5] and hinokiol-1-one 3 beta, 12-dihydroxyabieta-8,11,13-triene-1-one] [6], in addition to the sesquiterpene 8 alpha -acetoxyelemol [7]. Both physical and spectral data were used for structure determination and all isolates were evaluated for their hepatoprotective activity. Compounds 1 and 4 were the most effective in reducing the elevated liver enzymes as indication for liver protection
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Plantes médicinales
/
Sesquiterpènes
/
Terpènes
/
Tétrachloro-méthane
/
Diterpènes
/
Lésions hépatiques dues aux substances
langue:
Anglais
Texte intégral:
Pak. J. Pharm. Sci.
Année:
2012
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