[Oculomotor function in idiopathic Parkinsonian patients]

ABSTRACT

Parkinson could be regards the most prevalent degenerative disorder in the central nervous system. In addition to neuromuscular disorders, some degree of oculomotor dysfunction may be observed in these patients. The assessment of oculomotor system function may provide a viewpoint about the balance status of Parkinosonian patients and cold be regarded as an appropriate tool for the extent of movement disorders. The purpose of this study was the evaluation of oculomotor system in patients with idiopathic Parkinson's disease. Certainly, better understanding of mechanisms involved in this disorder, may help in designing rehabilitation programs and quality of life increment in these patients. In an analytic cross-sectional study, 30 patients [M18, F 12] with idiopathic Parkinson's disease and 30 [M 20, F 10] normal subjects, aged 35-70 years, were evaluated. Gain and phase of smooth pursuit eye movements [during horizontal and vertical situations] were recorded in 0.2 Hz velocity for all participants. Independent T and man-Whitney U tests [when the data distributions were not normal] were used for the comparison of mean gain and phase of responses between groups. Data analysis was carried out by SPSS 15. The average of pain, except for horizontal right eye condition, in normal subjects was significantly higher than patients with Parkinson's disease [P < 0.05]. Additionally, the average of phase, except for horizontal right eye condition, in patients with Parkinson's disease was significantly increased compared to normal subjects [P<0.01]. Serious oculomotor system dysfunction, both in horizontal and vertical situations, in idiopathic Parkinsonian patients may representative of dopaminergic control decrement in these patients