Effect of praziquantel treatment on serum protein pattern serum ceruloplasmin and blood glutathione in healthy and schistosoma mansoni-infected mice

ABSTRACT

The effect of praziquantel treatment on serum protein pattern, serum ceruloplasmin and blood reduced glutathione [GSH] content was investigated in healthy and schistosome-infected mice. Schistosoma mansoni infection in mice resulted in a moderate decrease in serum total protein accompanied by a significant decrease in albumin fraction and alpha 1 globulins with insignificant increase in B and Y globulins. Moreover, the results indicated that infection caused a marked decrease in both serum ceruloplasmin level and blood GSH content. Treatment of the infected mice with praziquantel [2 x 500 mg/Kg] improved the deranged serum protein pattern and restored the blood GSH content to normal level. However, such a treatment slightly improved the lowered level of serum ceruloplasmin in infected animals. Praziquantel given to normal mice did not affect any of these findings are discussed