Effect of homatropine eye drops on pain after photorefractive keratectomy: a pilot study

To assess the effect of homatropine eye drops on pain after photorefractive keratectomy [PRK]. This randomized, double masked, interventional study included 15 patients [30 eyes] who underwent bilateral PRK. After operation, patients received homatropine eye drops, 4 times daily in only one eye [homatropine eye]. The level of pain was evaluated using visual analogue scale [VAS], verbal rating scale [VRS] and pain rating index [PRI] at 0.5, 24 and 48 h after operation. The level of pain was statistically similar between the two eyes half an hour after operation, however, homatropine eyes had significantly less pain 24 h after operation compared to fellow eyes [2.5 +/- 1.9 vs 5.3 +/- 2.5, P = 0.004 for VAS, 2.0 +/- 1.2 vs 3.2 +/- 0.9, P = 0.023 for VRS, and 9.4 +/- 5.7 vs 16.0 +/- 9.0, P = 0.031 for PRI]. Also, 48 h after surgery, the pain scales were less in the homatropine eyes [2.3 +/- 1.7 vs 4.0 +/- 2.1, P = 0.014 for VAS, 1.6 +/- 1.0 vs 2.5 +/- 1.0, P = 0.038 for VRS, and 6.8 +/- 5.7 vs 12.0 +/- 8.9, P = 0.005 for PRI]. No delayed epithelial healing was observed. Homatropine eye drops may be useful for reducing pain after Photorefractive keratectomy