[Protein S, C and antithrombin deficiency: Association to myocardial infarction and thromboembolism in young]

ABSTRACT

The pathogenesis of myocardial infarction [MI] in young involves new factors including constitutional or acquired thrombophilia. To determine in patients association between coagulation factors deficiency, myocardial infarction and cardiovascular events during follow-up. Protein C [PC], PS and antithrombin [AT] were screened in 50 patients admitted for acute MI and in a healthy control group. Univariate and multivariate analysis were performed using SPSS 11.5 version. PS and PC deficiency were associated to MI [respectively 24% vs 0%, p=0.001 and 14% vs 0%, p=0.016], independently for PC. No AT deficiency was detected in both groups. During followup, PS and C deficiency were predictive for venous thrombosis [p<0.05] and PS deficiency for pulmonary embolism. Protein C and S deficiency may play an important role in MI in young and also in thromboembolic complications during follow-up. Nevertheless, therapeutic implications remain controversial