Detection of early glaucomatous damage in pseudo exfoliation syndrome by assessment of retinal nerve fiber layer thickness

ABSTRACT

To detect early glaucomatous changes in pseudo exfoliative patients with normal intraocular pressure [IOP], visual field and optic nerve head appearance; by measuring retinal nerve fiber layer [RNFL] thickness using optical coherence tomography [OCT]. A prospective observational case-control study. Twenty non-glaucomatous [normal IOP, fundus and visual field] pseudo exfoliative patients and 20 age matched healthy control subjects. The RNFL thickness [global and four quadrants] was assessed using combined imaging system OTI [OCT/SLO] and compared with age matched normal control subjects. The RNFL in patients with pseudo exfoliation syndrome [PXS] was significantly thinner in all quadrants except the nasal quadrant compared to the control group [p less than 0.05]. Measurement of RNFL thickness by OCT is useful in detecting early RNFL damage which in turn provides clinically relevant information in detecting early glaucomatous changes in pseudo exfoliative patients