Significance of grade in relation to oestrogen receptor status and Ki-67 proliferative index in cancer breast

The objective of this study was to determine the relationship between oestrogeu receptor [ER] status and Ki-67 proliferation index in relation to age of the patients, grade, size of tumours and lymph node involvement in carcinoma of the breast in a local population. It is a cross-sectional and descriptive study. The study was conducted during a period of 12 months in the Department of Morbid Anatomy and Histopathology, University of Health Sciences, Lahore. A total of 100 cases of carcinoma of the breast were collected and immunohistochemistry was carried out on all the tumours. Statistical analysis was performed by using SPSS 16. A significant inverse correlation between ER and grade of tumours was observed with a p-value being < 0.005 and r value of -0.281. As a conclusion it was found that ER and grade of tumours had significant inverse correlation, whereas there was no significant correlation between Ki-67 proliferative index and grade of tumours. It was also concluded that there was no significance of age of the patients, tumour size and lymph node involvement