[ impact of vitamin E on glycemic control and lipid profiles in type 2 diabetes patients]

ABSTRACT

Diabetic complications have been related to hyperlipidemia and hyperglycemia. Alpha -tochoferol has antioxidant effects and can improve lipid profiles. We evaluated the effect of vitamin E supplementation on glucose, insulin and lipid profiles in type 2 diabetic patients. In a randomized clinical trial, 31 patients included 14 men and 17 women [51.9 +/- 5.9 year] with type 2 diabetes were randomly divided into treatment with vitamin E [800 mg/day] and placebo groups for 2 months. Plasma glucose, Insulin and lipid profiles were measured at the beginning and at the end of 3 months supplementation. The paired and independent t-test was used for analyzing of data. Anthropometric indexes were stable throughout the study. Vitamin E administration lowered fasting plasma insulin concentrations [28.25 +/- 2.37 and 27.8 +/- 2.56, p<0.016] plasma triglyceride concentration [279.41 +/- 194.99 and 212.48 +/- 85.18 p <0.03]. The plasma glucose and the other lipid profiles did not change after vitamin E consumption for 2 months. We need more research to establish beneficial effect of vitamin E intake in type 2 diabetic patients