Flowcytometric analysis of T-lymphocytes and serum tumour necrosis factor alpha [TNF- alpha] levels in schistosoma mansoni patients
Journal of the Egyptian Society of Parasitology. 2007; 37 (3): 1065-1074
Dans Anglais
| IMEMR
| ID: emr-135363
ABSTRACT
Analysis of T-lymphocytes by flowcytometry, estimation of serum TNF-alpha level by solid phase enzyme amplified sensitivity immunoassay [EASIA] and IHAT were done for chronic schistosomiasis mansoni patients without hepatic fibrosis, with hepatosplenomegaly and 20 healthy controls. The sensitivity and specificity of IHAT in schistosomiasis mansoni were 85% and 90% respectively. Chronic schistosomiasis mansoni patients showed increase in CD8% [27.3 +/- 5.3] and decrease in CD4% [44.2 +/- 4.68]. Hepatosplenomegaly cases showed increase in CD4% [46.5 +/- 4.1] and decrease in CD8% [23.2 +/- 2.18]. Serum level of TNF-alpha was significantly higher in cases with hepatosplenomegaly compared to either cases of chronic schistosomiasis mansoni or controls. No significant difference was between chronic schistosomiasis mansoni patients and controls. A correlation between hepatosplenomegaly and increase of CD4 and/or decrease of CD8 and significant high level of TNF-alpha indicated TNF-alpha role in granuloma formation
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Indice:
Méditerranée orientale
Sujet Principal:
Lymphocytes T
/
Antigènes CD4
/
Facteur de nécrose tumorale alpha
/
Antigènes CD8
/
Cytométrie en flux
/
Granulome
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
J. Egypt. Soc. Parasitol.
Année:
2007
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