[Comparison of salivary alkaline phosphatase in periodontitis patients and healthy subjects]

ABSTRACT

Periodontitis is a chronic multi factorial infectious disease, characterized by the irreversible destruction of collagen fibers and other matrix constituents of the gingival tissues, periodontal ligament and resorption of alveolar bone around the teeth with the formation of periodontal pocket. Host response to periodontal disease include the production of different enzymes that are released by stromal, epithelial or inflammatory cells associated with cell injury and cell death. The aim of this study was comparison of Salivary alkaline phosphatase enzyme in mild and moderate to severe periodontitis patients and healthy subjects with normal periodontium. In this experimental study, unstimulated saliva of 20 patients with mild periodontitis, 20 patients with moderate to severe periodontitis, and 20 subjects with healthy periodontium were collected. The mean levels of alkaline phosphatase salivary enzymes were measured by kinetic system, finally, data were analyzed by ANOVA and TUKEY tests. Mean level of Alkaline phosphatase salivary enzyme in healthy gingival group was 9.25 +/- 4.3, in mild periodontitis group was 21.3 +/- 7.6 and in moderate to severe periodontitis group was 33. 75 +/- 11. 9 and there was significant differences between three groups [P<0.05]. The results of this study showed that the mean level of Alkaline phosphatase salivary enzymes in periodontally patients was greater than healthy subjects and these enzymes can be good markers for determining amount of destruction of periodontal tissues