Efficacy of herbal coded Hepcon on drug induced hepatitis in experimental animals through histopathological and biochemical analysis
Pakistan Journal of Pharmaceutical Sciences. 2013; 26 (5): 991-997
Dans Anglais
| IMEMR
| ID: emr-138421
ABSTRACT
Drug-induced liver injury is the leading cause for more than 50 percent of cases of acute liver failure. This study was conducted on herbo-mineral formulation "Hepcon" to evaluate its hepatoprotective effects in drug induced hepatitis in experimental animals. The liver injury was introduced with over dosage of non steroidal anti-inflammatory drugs [NSAIDs] and carbon tetrachloride [CCl[4]]. The herbo-mineral formulations "Hepcon" consist of Zingiber officinale, Piprum nigrum, Ammonium chloride and Arsenic trioxide [Hartal warqi]. The aqueous extraction was administered to experimental animals. Thereafter their LFTs, IgG, and tissue pathology was studied. It was observed on the basis of biochemical and histopathological analysis that animals which were subjected to Hepcon became normal in 60 days whereas those as control group did not showed improvements and most of them died. It was concluded that the efficacy of Hepcon to treat liver injury caused by CCl[4] and NSAIDs is very effective, and no side effects were noticed
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Indice:
Méditerranée orientale
Sujet Principal:
Lapins
/
Facteurs temps
/
Tétrachloro-méthane
/
Marqueurs biologiques
/
Anti-inflammatoires non stéroïdiens
/
Préparations à base de plantes
/
Modèles animaux de maladie humaine
/
Foie
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Pak. J. Pharm. Sci.
Année:
2013
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