prognostic value of the immune status in breast cancer patients

ABSTRACT

This work has been carried out at Kasr El Aini of Radiation Oncology and Nuclear Medicine [NEMROCK] from the 15th of September 1982 to the 15th of June 1983, studying the prognostic value of the immune status in breast cancer. All patients [98 females] were referred after modified radical mastectomy to receive adjuvant radiotherapy and or chemotherapy or no treatment. Patients were subjected to clinical examination, laboratory studies, radiological examinations, radionuclide scanning, histopathological evaluation. Sixty eight patients were subjected to immunological studies. Suppressed cell-mediated immunity [CMI] was diagnosed if one or both of the skin tests were negative and/or if low absolute count or low stimulation index were obtained compared to normal controls. At sit months post-treatment, disease free survival was significantly higher among patients who were postmenopausal with early disease, round cell infiltration in tumour bed, sinus histiocytosis in axillary lymph nodes and normal cell mediated immune status