Preparation and evaluation of pellets using acacia and tragacanth by extrusion-spheronization

ABSTRACT

Extrusion-spheronization is an established technique for the production of pellets for pharmaceutical applications. In this study, the feasibility and influence of the incorporation of acacia, by itself and in combination with tragacanth, on the ability of formulations containing 2 model of drugs [ibuprofen and theophylline] to form spherical pellets by extrusion-spheronization was investigated. Formulations containing different ratios of acacia and tragacanth [82, 91, and 100] and different drug concentrations [20%, 40%, and 60%] were prepared, on the basis of a 3[2] full factorial design. Pellet properties, such as aspect ratio, sphericity [image analysis], crushing strength and elastic modulus [mechanical tests], mean dissolution time, and dissolution profiles were evaluated. The effect of particular factors on responses was determined by linear regression analysis. The sphericity, drug release rate, and the mechanical properties of the pellets were affected by the amounts and types of the drugs, and the ratio of the gums. Acacia, relative to tragacanth, produced pellets with higher mechanical strength and a faster drug release rate. Addition of small amounts of tragacanth to ibuprofen formulations resulted in matrix pellets with slow drug release. The results showed that acacia and tragacanth can be used successfully as 2 natural binders in the pellet formulations