Association between CC10 +38A/G polymorphism and asthma risk: a meta-analysis

ABSTRACT

A number of studies conducted to assess the association between Clara cell 10-kDa protein [CC10] +38A/G polymorphism and susceptibility to asthma have yielded inconsistent and inconclusive results, in the present study, the possible association was assessed by a meta-analysis. Relevant articles were identified for the period ranging from Jan 1998 up to March 2013. Pooled odds ratios [OR] with 95% confidence intervals [Cl] were appropriately derived from fixed effects or random-effects models. Ten case-control studies with a total of 1529 asthma cases and 2399 controls were included in this meta-analysis. The association between CC10 +38A/G polymorphism and asthma risk was determined in dominant model, recessive model, additive model, and codominant model. In dominant model, CC10 +38A/G polymorphism seemed to be associated with elevated asthma risk [OR = 1.62; 95% Cl, 1.23-2.12; P = 0.0005]. Subgroup analyses by ethnicity also found significant associations between this polymorphism and asthma risk in Asians and Caucasians. Results from other genetic models further identified this possible association. This meta-analysis suggests that CC10 +38A/G polymorphism confers asthma risk