Laryngeal squamous cell carcinoma: demonstration of human papilloma virus [HPV] antigen and possible associated condylomatous changes of the epithelium

ABSTRACT

Twenty biopsies of laryngeal squamous cell carcinoma were subjected to histological examination in this study after being fixed in 10% buffered formalin, embedded in paraffin and stained with both haematoxylin and Eosin [H and E] and immunoprexidase stain. 13 cases showed papillomatous changes while 7 cases showed flat type condylomatous changes. 50% of the total cases showed positive reactivity with immunoperoxidase stain. 53.8% of the tumours with the papillomatous changes and 42.9% of those with flat type changes showed positive reactivity for HPV antigen particles