Antihyperglycemic and hypolipidemic effects of Hibiscus schizopetalus [Mast] Hook in alloxan-induced diabetic rats
Pakistan Journal of Pharmaceutical Sciences. 2014; 27 (1): 83-89
Dans Anglais
| IMEMR
| ID: emr-142984
ABSTRACT
The antihyperglycemic and hypolipidemic activities of Hibiscus schizopetalus [Mast] Hook [Malvaceae] flower and leaves extracts were investigated in alloxan-induced diabetic rats. The hypoglycemic activity of both the extracts [100mg/kg, body weight] was tested in fasting normal rat, glucose loaded rats. Observation on body weight was also recorded. The extracts showed a significant [P<0.001] reduction in blood glucose level in normal fasting rats. In glucose tolerance test, significant [P<0.01] decreased observed in all glucose loaded animals. While in alloxan induced diabetic rats, the percent blood glucose reduction was 59.94% and 45.14% in extracts treated groups. The results obtained were compared with the reference standard drug Tolbutamide [100mg/kg, body weight]. The diabetic rats showed sign of decreased in their body weight during the treatment period. Cholesterol and triglycerides levels were significantly decreased [P<0.001] by HFE. The results obtained demonstrated the potential hypoglycemic activity of methanolic extracts of H. schizopetalus. There is need of bioassay-directed assay of the active principles responsible for the anti-diabetic activity. The methanolic extracts showed the presence of carbohydrates, alkaloids, steroids, terpenes, saponins and glycosides.
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Indice:
Méditerranée orientale
Sujet Principal:
Rats
/
Tolbutamide
/
Extraits de plantes
/
Diabète expérimental
/
Alloxane
/
Hypoglycémiants
/
Phytothérapie
/
Hypolipémiants
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Pak. J. Pharm. Sci.
Année:
2014
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