In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum thunb

ABSTRACT

The aim of this study was to evaluate in vitro anti-proliferative [tested on MCF-7, MDA-MB-231, and MCF- 10A cell lines] and anti-inflammatory [evaluated as inhibition of prostaglandin E[2] synthesis catalyzed by cyclooxygenase-2] effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC[50] values ranging from 93 to 198 microg/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with IC[50] values = 2.0, 5.4, and 12.7 microg/mL, respectively. These results indicate that V. bracteatum leaves and fruits could be useful source of anti-cancer and anti-inflammatory compounds.