Expression of T-cell immunoglobulin- and mucin-domain-containing molecule-3 on lymphocytes from Henoch-Schoenlein purpura patients
Iranian Journal of Pediatrics. 2013; 23 (3): 345-348
Dans Anglais
| IMEMR
| ID: emr-143203
ABSTRACT
To investigate T-cell immunoglobulin domain and mucin domain-containing molecule-3 [Tim-3] and its ligand galectin-9 mRNA expression in peripheral blood mononuclear cells [PBMCs] from Henoch-Schoenlein Purpura [HSP] patients. Quantitative real-time reverse transcription-polymerase chain reaction [PCR] was used to examine the mRNA expression of Tim-3 and its ligand galectin-9 in PBMCs from HSP patients. ELISA methods were used to examine the levels of serum IFN-gamma and immunoglobulin A1 [IgA1]. The Spearman rank test was used for correlation analysis between Tim-3, galectin-9 mRNA expression and serum IFN-gamma and IgA1 levels, respectively. The results showed that Tim-3 and galectin-9 mRNA expression was obviously higher in patients, which was closely correlated with serum IFN-gamma and IgA1, respectively. The results suggested that Tim-3/Tim-3L may be related to the pathogenesis of HSP
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Immunoglobuline A
/
Immunoglobulines
/
Test ELISA
/
Lymphocytes
/
Lymphocytes T
/
Interféron gamma
/
Réaction de polymérisation en chaine en temps réel
/
Protéines membranaires
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Iran. J. Pediatr.
Année:
2013
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS