Anti-proliferation effect of Hevea brasiliensis latex B-serum on human breast epithelial cells
Pakistan Journal of Pharmaceutical Sciences. 2012; 25 (3): 645-650
Dans Anglais
| IMEMR
| ID: emr-144419
ABSTRACT
The rubber tree [Hevea brasiliensis] extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell lines MCF-7 and MDA-MB231. The results showed that the latex whole B-serum and DBP sub-fraction exerted a specific anti-proliferation activity against cancer origin cells MDA-MB231 but had little effect on non-cancer-origin cells. On the other hand, the anti-proliferative activity was diminished in the pre-heated B-serum fractions. With the low toxicity that the B-serum demonstrated previously in Brine Shrimp Lethality Test [BSLT], the present results suggest the potential use of the B-serum subfractions in cancer treatment
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Artemia
/
Pain
/
Région mammaire
/
Lignée cellulaire tumorale
/
Prolifération cellulaire
/
Cellules épithéliales
/
Latex
Limites du sujet:
Animaux
/
Femelle
/
Humains
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Pak. J. Pharm. Sci.
Année:
2012
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS