In-vitro anti-inflammatory and anti-arthritic activity of whole plant extracts of Coldenia procumbens linn.

ABSTRACT

Phytochemical investigations, in-vitro anti-inflammatory and anti-arthritic activities of whole plant extracts of Coldenia procumbens Linn. by human red blood corpuscles [HRBC] membrane stabilization method and Inhibition of protein denaturation method respectively were carried out. The dried whole plant material was extracted by cold maceration with ethanol and the concentrated extract was fractioned with petroleum ether, chloroform and ethyl acetate. The phytochemical analysis of these fractions revealed the presence of flavonoids, glycosides, carbohydrates, reducing sugars, oils and fats. All the tested fractions of ethanolic extract of Coldenia procumbens Linn. showed significant anti-inflammatory and anti-arthritic activity at a concentration of 250 microg/ml. This effect was compared with known anti-inflammatory and anti-arthritic drugs such as Aspirin and Diclofenac sodium at the same concentration