Bile acid and cholinesterase activity as an early liver function tests for detection of organic solvent hepatotoxicity
Egyptian Journal of Occupational Medicine. 1990; 14 (1): 85-94
Dans Anglais
| IMEMR
| ID: emr-145555
ABSTRACT
Forty-six workers exposed to different types of organic solvents and fourteen workers far from exposure were included in this study. The exposed workers were classified into 3 groups according to the nature of the work and the type of solvent; group A [acetone, n-hexane-exposed workers], group B [toluene, xylene-exposed workers] and group C [trichloroethylene, isopropyl alcohol, methyl alcohol exposed workers]. Routine liver function tests appear normal. Serum bile acid and serum cholinesteracse were estimated in all workers. The results showed a significant increase in serum bile acid in all exposed groups compared with the non-exposed group. Serum cholinesterase activity was significantly lower in the exposed groups than the non-exposed group. From these results we can conclude that, serum bile acid and serum cholinesterase represent an early and sensitive tests for detection of organic solvent hepatotoxicity
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Indice:
Méditerranée orientale
Sujet Principal:
Acétone
/
Trichloroéthylène
/
Xylènes
/
Acides et sels biliaires
/
Cholinesterases
/
Éthanol
/
Foie
/
Tests de la fonction hépatique
/
Maladies professionnelles
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Egypt. J. Occup. Med.
Année:
1990
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