Evaluation of histopathological and biochemical hepatoprotective potentials of fagonia bruguieri a plant from Cholistan desert

ABSTRACT

Aerial parts of Fagonia Bruguieri [FB] [family, zygophyllaceae] were subjected to in vivo hepatoprotective study in order to validate its traditional use in hepatobiliary disorders, by native people of Cholistan desert, Pakistan. Experimental study. This study was conducted at PCR lab Multan. The animals were randomly divided into three groups, containing 10 rabbits in each group. Hepatoprotective effects of pre-treatment with aerial parts [ethanolic extract] of FB [500 and 750 mg/kg/day PO for 7 days] against CC1[4] [0.75 ml/kg, S/C] intoxicated rabbits were evaluated by serum biochemical parameters and liver histological observations. Silymarin [100 mg/kg/day PO for 7 days] was used as a standard hepatoprotective drug, CC1[4] intoxicated group had raised levels of SCOT, SGPT and ALP sTignificantly but TB level was not raised as compared to normal control group. FB extract [both doses of 500 and 750 mg/kg] showed hepatoprotection as obvious by significant reinstatement of levels of SCOT, SGPT and ALP while TB level was not changed significantly, when compared with CC1[4] intoxicated group. B[oth] doses of FB extract were well comparable with silymarin. Histopathological examination of the liver tissue further corroborated these results. Therefore, the conclusion of the present study supports the traditional believes on hepatoproptective effects of Fagonia Bruguieri [aerial parts]