Epoxidationof ferutinin by different fungi and antibacterial activity of its metabolite

ABSTRACT

Structural transformation of the sesquiterpene ester, ferutinin [1], by suspended fungal cultures of Aspergillus niger, Rhizopus stolonifer, and Fusarium lini, resulted in the formation of a metabolite. This metabolite was identified as ferutinin alpha-epoxide [2], by different spectroscopic techniques. Metabolite 2 showed a good antibacterial activity against Staphylococcus aureuscompared to ferutinin [1]