IJRM-Iranian Journal of Reproductive Medicine. 2014; 12 (10): 667-672
Dans Anglais
| IMEMR
| ID: emr-148981
ABSTRACT
Despite extensive progress in IVF techniques, one of the most difficult problems is the variability in the response to controlled ovarian hyperstimulation [COH]. Recent studies show the effects of individual genetic variability on COH outcome. To evaluate the correlation between LHbeta G1502A polymorphisms in exon 3 of the LH gene and ovarian response to COH. A total of 220 women treated with a long protocol for ovarian stimulation were studied. Three genotypes of GG, GA and AA were detected by polymerase chain reaction-restriction fragment length polymorphism [PCR-RFLP] analysis. In total, 34 [17%] patients were poor responders, 154 [77%] were normal responders and 12 [6%] were hyper responders. The most frequent genotype was GA [55.5%] whereas 44.5% of patients showed GG genotype and there was no patient with AA genotype. In total 54.5% of normal responders, 61.8% of poor responders and 50% of hyper responders showed GA genotype. Our results did not establish a significant relationship between this polymorphism and the ovarian response. Therefore it is still very difficult to use the genotype of patients for prediction of the ovarian response to stimulation
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Indice:
Méditerranée orientale
Sujet Principal:
Ovaire
/
Polymorphisme génétique
/
Polymorphisme de restriction
/
Réaction de polymérisation en chaîne
/
Exons
/
Études transversales
/
Sous-unité bêta de l'hormone lutéinisante
/
Mutation
Type d'étude:
Étude de prévalence
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Iran. J. Reprod. Med.
Année:
2014
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