[Effect of common paraoxonase 1 polymorphism [Q192R] on atherosclerosis risk in referred diabetic patients to Tabriz Shahid Madani heart hospital in 2010]

ABSTRACT

Paraoxonase is a HDL-associated enzyme implicated in the pathogeneses of atherosclerosis by protecting lipoproteins against peroxidition in numerous studies. Its biallelic gene polymorphism at codon 192Q>R has been associated with coronary artery disease [CAD]. Therefore, in the present study the role of polymorphism paraoxonase 1 gene was evaluated for CAD in diabetic patients. In this case- control study, peripheral blood was taken from 105 CAD patients diagnosed with angioplastically and 95 CAD individuals with no history of diabetes from Northwest of Iranian population. The abundance of mutant alleles of the 192Q>R paraoxonase were determined by PCR-RFLP. The abundance of RR allele in diabetic group was significantly higher than in selected group with no diabetic history [41.1% in diabetic vs. 24.5% in non-diabetic individuals]. Regarding significant prevalence of RR allele and considering ethnic diversities like Turk, Kurd, Lore and others living in Iran, it appears that other polymorphism of this gene like 163T>A and 55L>M is needed to be studied in diabetic patients, which their relations to atherosclerotic problem has been already determined.