Atherogenic index of plasma in normotensive adults with type 1 diabetes mellitus

ABSTRACT

Type 1 diabetes is an organ specific autoimmune disease characterized by a progressive cell-mediated destruction of beta cells of the pancreas which leads to an absolute dependence on insulin for survival and maintenance of health. The present study was designed to look at the levels of atherogenic index of plasma [AIP] in normotensive adults with type 1 diabetes mellitus. The study was also intended to look for the difference, if any, in AIP levels between type 1 diabetics and the control healthy group. Observational and comparative study. This study was conducted at Department of Biochemistry and Clinical Chemistry, Khyber Medical College, Peshawar from July 2006 to December 2006. This study was conducted at Department of Biochemistry and Clinical Chemistry, Khyber Medical College, Peshawar from July 2006 to December 2006. In this study 30 patients with Normotensive Type 1 Diabetes Mellitus and 30 healthy control individuals were included. Blood samples of patients and control individuals were collected and analyzed for flucose, lipid profile and AIP was evaluated. The age and the body mass index [BMI] were having no significant statistical difference between the patient and the control group. Blood glucose, lipid profile and AIP were found to be significantly higher in normotensive type 1 diabetic patients when compared with control subjects. The study emphasizes that the determination of Atherogenic index of plasma as a routine measure can be used as an early predictor of atherosclerotic complications in diabetes mellitus