[Association of LXRbeta rs17373080 polymorphism with obesity and obesity-related phenotypes in an Iranian population]

ABSTRACT

Liver X receptor Beta [NR1H3] has a pivotal role in carbohydrate and lipid metabolism and is located in an obesity susceptibility region, and genetic variations in it may play a role in etiology of human obesity. This study aims to assess the association of the LXRbeta rs17373080 polymorphism with obesity and related traits. A total of 435 unrelated subjects, including 160 obese, 201 overweight and 74 controls randomly selected from Mashhad city, were enrolled in the present case-control study. The anthropometric and biochemical parameters were measured and DNA samples were genotyped by the TaqMan assay. Allelic and genotypic frequencies showed no significant associations with obesity and related traits, even after age and gender adjustment. By logistic regression using a dominant model, the odds ratios for the obesity were 0.85 [0.46-1.57] for genotype CG and 1.14 [0.48-2.69] for genotype GG, compared with the genotype CC as a reference. The allelic frequency of the LXRbeta gene variant in whole population and also in three BMI groups was in the Hardy-Weinberg equilibrium. This study revealed no association between LXRbeta rs17373080 polymorphism and the risk of obesity in an Iranian population, suggesting this SNP is not a major contributor to risk of obesity