Colchicine and NSAID combination causing acute kidney injury

ABSTRACT

Colchicine is used mainly for the treatment of gout and familial mediterranean fever. The use of colchicine is limited by its toxicity, and colchicine overdose is associated with a high mortality rate. Herein, we are reporting a young man who presented to the emergency department after ingesting 13.5 mg of colchicine and 1200 mg of aceclofenac [non-steroid anti-inflammatory drug] for deliberate self harm. He developed acute kidney injury, metabolic acidosis, and bradycardia after admission. A combination effect of non-steroid anti-inflammatory drug and colchicines was responsible for this event