Morphological and histological changes in placenta of hypertensive and gestational diabetic women

ABSTRACT

To correlate the morphological and histo-pathological changes in placenta observed in normal, diabetic and hypertensive pregnancies. A cross sectional study. This study was carried at the department of Gynae and Obs Taluka hospital Hala, and Basic health unit Hala from 1[st] January, 2014 to 30[th] June, 2014. For this experimental study statistical analysis was carried on SPSS-11.0 version. Total 90 cases studied were divided in three equal groups. All placentae were processed through stages for final histo-pathological examination. The study showed that discoid shape were significantly less 4[13.3%] in hypertensive as compared to 16 [53.3%] diabetic and normal placentae [p<0.01], bilobed in 6 [20.0%] diabetic placenta. In hypertensive placenta 15[50%] had central attachment of umbilical cord, diabetic 22 [73.3%] and normal 30[100%]. Central thickness [Mean +/- S.D +/- SEM] of hypertensive placenta 2.2 +/- 0.58 +/- 0.11 were significantly less [p<0.01] as compared to normal placenta 3.0 +/- 0.03 +/- 0.01 but diabetic placenta 3.8 +/- 1.15 +/- 0.21 were significantly high [p<0.01] as compared to hypertensive and normal placenta. Gestational diabetes and hypertension had significant t-test that causes morphological changes in placenta that affects fetal and maternal wellbeing. This study is helpful for those who are concerned for mother and child health