[Evaluation of analgesic effect of sesame oil and lecithin diets in hot plate and formalin test on aged male rats]

ABSTRACT

Sesame oil is applied in physiological research as a solvent. It contains unsaturated fatty acids such as linoleic acid, sesamol and lecithin. In his research effect of dietary sesame oil on pain perception was studied. N-MRI male rats [360 +/- 20 g] were used. Animals divided to two groups 1] control group and 2] experimental group [three subgroups that ate dietary plats that contain 10% sesame oil for 28, 42 and 56 days respectively and a subgroup ate dietary plats that contain 1% lecithin]. After 28, 42 and 56 days pain was evaluateded by digital hot plate and formalin test. Data was analyzed by one way ANOVA or T- test. Hot plate test Sesame oil diet decreased pain in the 28, 42, 56 days significantly. Formalin test Sesame oil diet decreased pain only in 42 days [p<0.02] significantly in early phase. Sesame oil diet decreased pain in the 28 days [p<0.0001] and 42 days [p<0.03] and 56 days [p<0.001] significantly in late phase of formalin test and also we found significant difference between control and lecithin group [p<0.006] in late phase. Hot plate test Dietary plats [10% sesame oil] decreased acute pain perception in all experimental groups [p<0.03]. Our data indicated that dietary sesame oil could increase pain threshold. It seems that sesame oil lecithin [as a source for acetylcholine] or unsaturated fatty acid [altered plasma membrane properties or PGs metabolism] involve in this pain threshold alternation