Histopathological changes in the ovaries and uteri of female mice after chronic adminstration of morphine and butorphanol tartrate [stadol]

This work was done to study the drastic effects of narcotics on female genital system. Morphine and stadol, the two widely used narcotics in medical fields, were used in this study. They were injected intraperitoneally twice daily for ten days to adult female non- pregnant mice. It was observed that both drugs caused histological changes in the ovaries of treated animals in the form of decrease in the number of primary follicles with increase in the number of atretic follicles and suppression of maturation to Graffian follicles. In addition, both morphine and stadol administration caused histological changes in the uteri of treated mice. These changes included thinning of uterine wall, the endometrial glands are scarce, the endometrial stroma is loose and the myometrium showed marked atrophied thin muscles. The histopathological changes in the ovaries and uteri were more marked in morphine treated animals than in stadol treated group