Electrolytes disturbance and cyclosporine blood levels among kidney transplant recipients

ABSTRACT

Kidney transplantation is associated with various biochemical abnormalities such as changes in serum blood level of sodium [Na], potassium [K], calcium [Ca], and phosphorous [P]. Although cy-closporine [CsA] is used commonly the prevalence of its side effects, including electrolytes disturbance, is not well understood. To find the prevalence of electrolytes disturbance and its relation to CsA blood levels. In a retrospective study 3308 kidney transplant recipients transplanted between 2008 and 2011 were studied. We evaluated the relation between serum Ca, P, Na, K and CsA trough [C[0]] and 2-hour post-dose [C[2]] levels. The meantSD age of recipients was 37 +/- 15 years; 63% of patients were male. Overall, C2 levels had correlation with Ca blood level [p=0.018; OR 1.13, 95%CI 1.02-1.25], CQ levels had also correlation with blood levels of P and Cr [p<0.001; OR 1.83, 95% CI 1.59-2.11]. Electrolyte disturbances are prevalent. Higher serum levels of CsA can worsen the allograft function by disturbing the serum P and Ca levels