Plasma met-enkephalin, beta-endorphin and leu-enkephalin levels in human hepatic encephalopathy
EMHJ-Eastern Mediterranean Health Journal. 2007; 13 (2): 257-265
Dans Anglais
| IMEMR
| ID: emr-156993
ABSTRACT
To address the role of the opioid system in the pathogenesis of hepatic encephalopathy [HE] we measured plasma met- enkephalin, beta -endorphin and leu- enkephalin in patients with different grades of HE compared to control subjects and patients with cirrhosis. Plasma met- enkephalin levels were significantly higher in patients with cirrhosis and all grades of HE than controls. Plasma beta levels were similar in the 3 groups. Plasma leu- enkephalin levels were significantly higher -endorphin in HE grades II, III and IV than in controls, patients with cirrhosis and HE grade I patients. Our results support data on the involvement of met- enkephalin and leu- enkephalin in the pathogenesis of HE and provide a rationale for the use of opioid receptor antagonists in the treatment of HE
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Leucine-enképhaline
/
Méthionine-enképhaline
/
Bêta-Endorphine
/
Encéphalopathie hépatique
/
Peptides opioïdes
/
Tests de la fonction hépatique
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
East Mediterr Health J.
Année:
2007
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS