Combination therapy with interferon and ribavirin for chronic hepatitis C infection in beta-thalassaemia major
EMHJ-Eastern Mediterranean Health Journal. 2009; 15 (4): 785-791
Dans Anglais
| IMEMR
| ID: emr-157380
ABSTRACT
Treatment of chronic hepatitis C virus [HCV] infection in transfusion-dependent betathalassaemia major patients is complicated by existing hepatic siderosis and the fear of ribavirinassociated haemolysis. We evaluated the efficacy and side-effects of combination interferon-alpha [INF] and ribavirin therapy for HCV-infected thalassaemia patients. A total of 17 patients were enrolled [10 nonresponders to INF monotherapy, 7 naive to treatment, mean age 23.1 years] and they received 12 months of combination therapy. The sustained virological response rate 6 months after treatment was 58.8%. Blood transfusion requirements during treatment temporarily increased by 36.6%. Combination therapy was tolerated by, and may be useful for, HCV-infected thalassaemia major patients
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Indice:
Méditerranée orientale
Sujet Principal:
Ribavirine
/
Transfusion sanguine
/
Interférons
/
Résultat thérapeutique
/
Bêta-Thalassémie
/
Association de médicaments
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
East Mediterr Health J.
Année:
2009
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