Antioxidant status and lipid peroxidation activity in evaluating hepatocellular damage in children
EMHJ-Eastern Mediterranean Health Journal. 2009; 15 (4): 842-852
Dans Anglais
| IMEMR
| ID: emr-157386
ABSTRACT
Serum levels of glutathione reductase [GR], glutathione S-transferase-alpha [GST-alpha] and malondialdehyde [MDA] were determined to evaluate their use in diagnosing hepatocellular damage in 75 children with liver disease. Except for level of GR in patients with HBV, GR, GST-alpha and MDA were raised significantly in patients compared with controls. At 100% specificity, the sensitivity of the 3 markers for detecting hepatitis B virus, hepatitis C virus and schistosomiasis infection respectively were 16.7%, 100.0% and 17.7% for GR; 33.3%, 62.1% and 38.2% for GST-alpha; and 25.0%, 10.3% and 29.4% for MDA. GR was more sensitive in hepatitis C infection, while MDA reflected changes in liver ultrasound and GST-alpha was the best indicator for histopathological changes
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Schistosomiase
/
Biopsie
/
Sensibilité et spécificité
/
Hépatite C
/
Stress oxydatif
/
Glutathione reductase
/
Glutathione transferase
/
Hépatite B
/
Maladies du foie
/
Tests de la fonction hépatique
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
East Mediterr Health J.
Année:
2009
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS