Assessment of response to tamoxifen among Iraqi patients with advanced breast cancer
EMHJ-Eastern Mediterranean Health Journal. 2000; 6 (2-3): 475-482
Dans Anglais
| IMEMR
| ID: emr-157820
ABSTRACT
Eighty-eight women presenting with locally advanced or metastatic breast cancer were treated with tamoxifen alone. Estrogen and progesterone receptors [ER and PR] were immunocytochemically analysed in mammary tumour cells obtained by fine needle sampling from 73 patients. Of the breast carcinomas, 34.2% were ER+/PR+ and 43.8% were ER-/PR-. The ER+ content increased with age in postmenopausal women. After tamoxifen treatment objective remission occurred in 39.7% of the women. The overall response rate was 53.3% in the ER+/PR- group and 73.1% in the ER+/PR+ group. However, the response elicited in a case of the ER-/PR- phenotype justified the randomized use of tamoxifen among patients in Iraq where the necessary requirements for hormone receptor assessment are almost unavailable
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Indice:
Méditerranée orientale
Sujet Principal:
Tamoxifène
/
Récepteurs des oestrogènes
/
Invasion tumorale
/
Métastase tumorale
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
East Mediterr Health J.
Année:
2000
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