TNF-alpha and homocysteine levels in type 1 diabetes mellitus
EMHJ-Eastern Mediterranean Health Journal. 2001; 7 (4-5): 679-688
Dans Anglais
| IMEMR
| ID: emr-157983
ABSTRACT
The role of homocysteine as an independent risk factor for vascular endothelial damage, and the possible link between homocysteine and tumour necrosis factor-alpha [TNF-alpha] as two synergistic risk factors for beta-cell apoptosis in type 1 diabetes mellitus was studied. Plasma homocysteine levels were significantly elevated in all diabetic patients compared with controls and diabetic patients with vascular complications showed higher elevations. Furthermore, homocysteine levels showed significant positive correlation with the degree of microalbuminuria. TNF-alpha levels were elevated in all diabetic patients compared with controls. These results may have therapeutic implications
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Hémoglobine glyquée
/
Cholestérol
/
Facteur de nécrose tumorale alpha
/
Apoptose
/
Hyperhomocystéinémie
/
Angiopathies diabétiques
/
Neuropathies diabétiques
/
Albuminurie
/
Homocystéine
/
Cholestérol LDL
Limites du sujet:
Adolescent
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
East Mediterr Health J.
Année:
2001
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