Serum concentrations of Helicobacter pylori IgG and the virulence factor CagA in patients with ischaemic heart disease

ABSTRACT

To compare the serum concentrations of IgG to Helicobacter pylori and its virulence factor CagA in patients with ischaemic heart disease [IHD], we recruited 120 patients with IHD [acute myocardial infarction [AMI] [n = 60]; unstable angina [UA] [n = 60]] and 60 sex- and age-matched healthy controls in this study. The seroprevalence of anti-H. pylori IgG was 86.7% in AMI, 91.7% in UA patients and 58.3% in the control group with mean titres of 33.2 U/ml [standard error [SE] 4.76], 57.96 U/ml [SE 7.54] and 25.72 U/ml [SE 4.01] respectively. The seroprevalence of anti-H. pylori in the patient groups was significantly higher than the control group. The mean levels of anti-H. pylori in the AMI and UA groups were also significantly higher than in the control group. The seroprevalence and mean titre of anti-CagA IgG did not differ significantly between patient and control groups