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Evaluation of specific biochemical indicators of Helicobactepylori-associated gastric cancer in Egypt
EMHJ-Eastern Mediterranean Health Journal. 2012; 18 (5): 501-507
Dans Anglais | IMEMR | ID: emr-158779
ABSTRACT
The aim of the study was to assess the accuracy of some specific biochemical indicators in discriminating between Helicobacter pylori-associated gastritis and H. pylori-associated stomach cancer [serum gastrin level, serum soluble E-cadherin and tissue COX-2 activity, as well as serodiagnostic markers for H. pylori infection] in order to find a simple diagnostic test that can reasonably predict the development of gastric cancer. The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pylori-associated gastritis and 20 individuals as the control group. Standard procedures and quality control measures were followed. Using cut-off values and ROC analysis to assess the diagnostic abilities of the biochemical indicators, E-cadherin showed the highest sensitivity [100%]. We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 microg/mL is essential
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Indice: Méditerranée orientale Sujet Principal: Tumeurs de l'estomac / Gastrines / Cadhérines / Helicobacter pylori / Sensibilité et spécificité / Gastrite Limites du sujet: Femelle / Humains / Mâle langue: Anglais Texte intégral: East Mediterr Health J. Année: 2012

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Indice: Méditerranée orientale Sujet Principal: Tumeurs de l'estomac / Gastrines / Cadhérines / Helicobacter pylori / Sensibilité et spécificité / Gastrite Limites du sujet: Femelle / Humains / Mâle langue: Anglais Texte intégral: East Mediterr Health J. Année: 2012