Pressure-controlled versus volume-controlled ventilation during one-lung ventilation in elderly patients with poor pulmonary function

ABSTRACT

The aim was to investigate the effects of two different ventilatory strategies Pressure-controlled ventilation [PCV] versus volume-controlled ventilation [VCV] in elderly patients with poor pulmonary function during one-lung ventilation [OLV]. The patients were enrolled into the study having poor pulmonary function [forced expiratory volume in 1 s <1.5 L] and undergoing radical resection of pulmonary carcinoma requiring at least 2 h of OLV. Patients were respectively allocated to VCV group and PCV group. The intraoperative data, arterial, and mixed venous blood gases were obtained at baseline, 20, 40, 60, 80, 100 and 120 min after OLV and end of surgery. The postoperative data had been recorded and arterial gas measurements were performed at 6, 12 and 24 h after surgery in Intensive Care Unit. Comparison of the VCV group and PCV group, PaO[2] and P[A-a]O[2] were higher and dead space to tidal volume was lower in the PCV group [P < 0.05] after the point of OLV +60, Ppeak was higher in the VCV group [P < 0.05]. There were significant advantages in PCV groups with regard to the PaO[2] of three points in postoperation, the duration of postoperative ventilation duration, intensive care duration of stay and the days stay in hospital after surgery. The use of PCV compared with VCV during OLV in elderly patients with poor pulmonary function has significant advantages of intraoperative and postoperative oxygenation and it might be a factor, which can beneficial to postoperative recovery