Comparative hepatorenal toxicity of some commonly used chemical environmental polutants

ABSTRACT

The major source of environmental contamination by pesticides is the deposits resulting from application of these chemicals to control pests. Daily oral administration of dose level of 1/20 LD50 of thallium sulfate as a rodenticide, permethrin as an insecticide and fluometuron as herbicide were give to three groups of adult male rats to study the harmful hazard effect of these perticide on the livers and kidneys of rats for three-month period and the results were compared with a control group. The results showed that there was a marked increase in SGPT in response to thallium sulfate and permethrin, while fluometuron induced a reduction in its level. Bilirubin was increased in all groups. On the other hand, there was very highly significant in the content of blood urea and serum creatinine. From these aforementioned results it was concluded that all these test compounds have potential harmful effects on both liver and kidney of rats