Protective effect of vitamin E against diabetes-induced oxidized LDL and aorta cell wall proliferation in rat

ABSTRACT

Hyperlipidemia and oxidized-low-density lipoproteins [Ox-LDL] are important independent cardiovascular risk factors that have been shown to stimulate vascular smooth muscle cell [VSMC] proliferation. The purpose of the present study was to investigate the effect of vitamin E on Ox-LDL, lipid profile, C-reactive protein [CRP], and VSMC proliferation of rat aorta. Male Wistar rats [n = 32] were divided into four groups namely sham [SH], control [C], non-treated diabetic, and vitamin E-treated diabetic [VETD] groups. Ox-LDL, lipid profile, CRP and VSMC proliferation of aorta were measured after 42 days. The results revealed that along with a significant increase in VSMC proliferation, the amount of CRP, Ox-LDL, and lipid profiles in diabetic rats. VSMC proliferation was significantly ameliorated, and elevated CRP, Ox-LDL, and lipid profiles were also restored to those of shams in VETD. These findings strongly support the idea that diabetes induces Ox-LDL-mediated oxidative stress and VSMC proliferation in aorta of rat and imply that vitamin E has a strong protective effect as an antioxidant