[Evaluation of knocking down of the RNAi mediated gamma globin repressor into K562 cells, for gene therapy of beta-thalassemia]
Pejouhandeh: Bimonthly Research Journal. 2011; 16 (5): 234-240
Dans Persan
| IMEMR
| ID: emr-163624
ABSTRACT
Background and Aim:
Beta-thalassemia is a genetic disorder manifested by the presence of anemia in adult patients. One approach to treatment of beta-thalassemia is induction of the fetal gamma-globin gene. One of the gamma-globin repressors is a complex called DRED [Direct repeat erythroid-definitive]. DRED is composed of TR2 and TR4 DNA binding subunits. The aim of this study was to set up the RNAi system to increase the expression of the gamma-globin gene
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Indice:
Méditerranée orientale
Sujet Principal:
Protéines de répression
/
ARN
/
Thérapie génétique
/
Bêta-Thalassémie
/
Cellules K562
/
Globines gamma
langue:
Persan
Texte intégral:
Pejouhandeh: Bimonthly Res. J.
Année:
2011
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